Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.35 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9845370 | 0.89 | HMGCR (0.34) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL9845373 | 0.89 | HMGCR (0.34) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL9845364 | 0.89 | HMGCR (0.34) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL9845365 | 0.87 | HMGCR (0.49) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL9577596 | 0.87 | HMGCR (0.49) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL9845362 | 0.87 | HMGCR (0.49) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL10408051 | 0.81 | HMGCR (0.35) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL10408048 | 0.81 | HMGCR (0.35) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL9845344 | 0.78 | ESR1 (0.40) | PTGS2MAPTHPGDTDP1KDM4E | |
| SCHEMBL9845347 | 0.78 | ESR1 (0.40) | PTGS2MAPTHPGDTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420266-A2 | Chromene or thiochromene derivatives, process for preparing the same, intermediate therefor, pharmaceutical compositions containing said derivatives and the use of said derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |