Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.35 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL982137 | 0.93 | MAP3K5 (0.34) | MAP3K5MAP3K6JAK3 | |
| SCHEMBL985732 | 0.93 | KDR (0.37) | NPY5RMAP3K5MAP3K6JAK1JAK3 | |
| SCHEMBL981843 | 0.92 | EPHX2 (0.38) | EPHX2NPY5RMAP3K5MAP3K6PIK3CD | |
| SCHEMBL984897 | 0.91 | EPHX2 (0.38) | EPHX2NPY5RMAP3K5MAP3K6PIK3CD | |
| SCHEMBL985153 | 0.90 | MAP3K5 (0.34) | EPHX2MAP3K5MAP3K6JAK3 | |
| SCHEMBL984240 | 0.90 | EPHX2 (0.40) | EPHX2NPY5RJAK1HSD17B10MEN1 | |
| SCHEMBL985719 | 0.89 | EPHX2 (0.40) | EPHX2NPY5RHSD17B10MEN1KMT2A | |
| SCHEMBL983541 | 0.88 | PIK3CD (0.41) | EPHX2MAP3K5MAP3K6PIK3CDPIK3R1 | |
| SCHEMBL984164 | 0.86 | PIK3CD (0.41) | EPHX2MAP3K5MAP3K6PIK3CDPIK3R1 | |
| Hydrochloric Acid SCHEMBL984192 | 0.86 | PTK2 (0.35) | MAP3K5MAP3K6KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | claimed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | EPHX2 594/4885NPY5R 289/4885MAP3K5 1564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.