SCHEMBL984926

SCHEMBL984926

O=C1CCNC2C=CC=CC12

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6285047 0.73
SCHEMBL7522453 0.72
SCHEMBL13709184 0.71
SCHEMBL7986248 0.69
SCHEMBL4991879 0.68 PRCP (0.50)
SCHEMBL3701448 0.67
SCHEMBL5445328 0.67
SCHEMBL2381676 0.67
SCHEMBL4058581 0.66
SCHEMBL13379597 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2291355-A2 NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS Panjab University (IN) 2011-03-09 EP claimed
WO-2009087684-A2 NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS PANJAB UNIVERSITY (IN) 2009-07-16 WO claimed
US-9006255-B2 Quinazoline derivatives MERCK PATENT GMBH (DE) 2015-04-14 US disclosed
EP-2632923-B1 QUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2015-01-14 EP disclosed
EP-2632923-B1 QUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2015-01-14 EP disclosed
EP-1941881-B1 Naphthalene derivatives for the treatment of dermatitis and psoriasis MITSUBISHI TANABE PHARMA CORP (JP) 2014-08-13 EP disclosed
US-20130210819-A1 QUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2013-08-15 US disclosed
WO-2012055466-A1 QUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2012-05-03 WO disclosed
US-8084611-B2 Process for preparing tetrahydroquinoline derivatives MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-12-27 US disclosed
EP-2007728-B1 A PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES MITSUBISHI TANABE PHARMA CORP (JP) 2011-11-16 EP disclosed
WO-2011131370-A1 MELT-GRANULATED FINGOLIMOD RATIOPHARM GMBH (DE) 2011-10-27 WO disclosed
WO-2003054000-A1 TEMPLATE-FIXED PEPTIDOMIMETICSAS INHIBITORS OF SERINE PROTEASES POLYPHOR LTD. (CH) 2003-07-03 WO disclosed
US-6452032-B1 ANTAGONISTS, AGONISTS, OR INVERSE AGONISTS PARTICULARLY FOR RETINOID AND FARNESOID RECEPTORS; REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION AND OF LIPID METABOLISM; DERMATOSES SUCH AS ACNE, PSORIASIS, ICTHYOSIS AND ECZEMA ALLERGAN SALES, LLC 2002-09-17 US disclosed
WO-2002070547-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY POLYPHOR LTD. (CH) 2002-09-12 WO disclosed
EP-1185277-A1 METHODS FOR MODULATING FXR RECEPTOR ACTIVITY Allergan Sales, Inc. (US) 2002-03-13 EP disclosed
EP-1185539-A1 ORGANOSILYL COMPOUNDS HAVING NUCLEAR HORMONE RECEPTOR MODULATING ACTIVITY Allergan Sales, Inc. (US) 2002-03-13 EP disclosed
WO-2000077011-A1 ORGANOSILYL COMPOUNDS HAVING NUCLEAR HORMONE RECEPTOR MODULATING ACTIVITY ALLERGAN SALES, INC. (US) 2000-12-21 WO disclosed
WO-2000076523-A1 METHODS FOR MODULATING FXR RECEPTOR ACTIVITY ALLERGAN SALES, INC. (US) 2000-12-21 WO disclosed
US-5710150-A ARGININE VASOPRESSIN ANTAGONISTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1998-01-20 US disclosed
EP-0716083-A1 BENZAZEPINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND INTERMEDIATE FOR THE SAME YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-06-12 EP disclosed