Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | F13A1 | P00488 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.49 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.49 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.49 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL553085 | 0.87 | KDM4E (0.70) | KDM4EF13A1SMN1; SMN2HIF1APLAAT3 | |
| SCHEMBL5707308 | 0.84 | KDM4E (0.77) | KDM4EF13A1SMN1; SMN2MAPK1HIF1A | |
| SCHEMBL425223 | 0.82 | TRPV1 (0.65) | HSP90AA1SMN1; SMN2KMT2AHPGDL3MBTL1 | |
| SCHEMBL16658733 | 0.81 | TRPV1 (0.68) | KDM4ESMN1; SMN2KMT2AMAPK1HIF1A | |
| SCHEMBL16658698 | 0.81 | TRPV1 (0.68) | KDM4ESMN1; SMN2KMT2AMAPK1HIF1A | |
| SCHEMBL16658696 | 0.81 | TRPV1 (0.68) | KDM4ESMN1; SMN2KMT2AMAPK1HIF1A | |
| SCHEMBL16658695 | 0.81 | TRPV1 (0.68) | KDM4ESMN1; SMN2KMT2AMAPK1HIF1A | |
| SCHEMBL5462618 | 0.81 | TRPV1 (0.68) | KDM4ESMN1; SMN2KMT2AMAPK1HIF1A | |
| SCHEMBL16658697 | 0.81 | TRPV1 (0.68) | KDM4ESMN1; SMN2KMT2AMAPK1HIF1A | |
| SCHEMBL5987763 | 0.79 | KDM4E (0.58) | KDM4EF13A1SMN1; SMN2KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |