Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8134000 | 0.93 | GAA (0.57) | TSHRALOX15HSD17B10GAAPOLB | |
| SCHEMBL11239159 | 0.84 | TSHR (0.63) | TSHRGAAALDH1A1LMNAKMT2A | |
| SCHEMBL9694299 | 0.77 | TSHR (0.54) | TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL9694018 | 0.77 | TSHR (0.47) | TSHRGAAALDH1A1NPC1RAB9A | |
| SCHEMBL23507546 | 0.76 | HSD17B10 (0.77) | TSHRALOX15HSD17B10GAAPOLB | |
| SCHEMBL30920967 | 0.76 | HSD17B10 (0.77) | TSHRALOX15HSD17B10GAAPOLB | |
| SCHEMBL31717947 | 0.76 | HSD17B10 (1.00) | TSHRALOX15HSD17B10GAAPOLB | |
| SCHEMBL26981196 | 0.76 | HSD17B10 (0.91) | TSHRALOX15HSD17B10GAAPOLB | |
| SCHEMBL11922747 | 0.74 | HSD17B10 (0.74) | TSHRALOX15HSD17B10GAAPOLB | |
| SCHEMBL9276912 | 0.74 | TSHR (0.54) | TSHRGAAALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061725-A | COGNITION ACTIVATORS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1991-10-29 | — | — | US | disclosed |
| EP-0408524-A1 | (Pyrrolidin-2-on-l-yl) acetamides as enhancers of learning and memory and pharmaceutical compositions comprising same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-01-16 | — | — | EP | disclosed |