Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.46 |
| ▸ | ASPH | Q12797 | 11/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 11/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | TET3 | O43151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694897 | 0.83 | KDM4E (0.47) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL8645026 | 0.81 | KDM4E (0.46) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL21222761 | 0.81 | KDM4E (0.46) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL517935 | 0.79 | KDM4E (0.55) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL480290 | 0.77 | KDM4E (0.40) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL28589292 | 0.77 | KDM4E (0.53) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL19694979 | 0.76 | KDM4E (0.68) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL29525861 | 0.74 | KDM4E (0.53) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL26598072 | 0.73 | KDM4E (0.41) | KDM4EASPHKDM8MAPTCYP1A2 | |
| SCHEMBL1002512 | 0.72 | KDM4E (0.52) | KDM4EASPHKDM8MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434965-A2 | Alkyl esters of 5-heterocyclic-pyridine-2,3-dicarboxylic acids and 5-heterocyclic 2-(2-imidazolin-2-yl) pyridines and methods for preparation thereof | AMERICAN CYANAMID COMPANY (US) | 1991-07-03 | — | — | EP | disclosed |