⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL29109509 | 0.72 | — | — | |
| Fluoromethane SCHEMBL6246388 | 0.72 | — | — | |
| SCHEMBL29859818 | 0.71 | — | — | |
| SCHEMBL1357 | 0.71 | — | — | |
| SCHEMBL7705271 | 0.71 | — | — | |
| SCHEMBL14722063 | 0.71 | — | — | |
| SCHEMBL29016 | 0.71 | — | — | |
| SCHEMBL876858 | 0.63 | — | — | |
| SCHEMBL9223832 | 0.63 | — | — | |
| Fluoride SCHEMBL8137697 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960351-B1 | PROPIONAMIDE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | HOFFMANN LA ROCHE (CH) | 2013-06-19 | — | — | EP | disclosed |
| CN-101326155-B | Propionamide compounds as antiinflammatory agents | HOFFMANN LA ROCHE | 2012-06-20 | — | — | CN | disclosed |
| US-7868031-B2 | Propionamide compounds as antiinflammatory agents | ROCHE PALO ALTO LLC (US) | 2011-01-11 | — | — | US | disclosed |
| CN-101326155-A | Propionamide compounds as antiinflammatory agents | HOFFMANN LA ROCHE (CH) | 2008-12-17 | — | — | CN | disclosed |
| EP-1960351-A1 | PROPIONAMIDE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| CN-100374438-C | Pre-organized tricyclic integrase inhibitor compounds | GILEAD SCIENCES INC (US) | 2008-03-12 | — | — | CN | disclosed |
| US-20070135500-A1 | Propionamide compounds as antiinflammatory agents | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| WO-2007065821-A1 | PROPIONAMIDE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-14 | — | — | WO | disclosed |
| CN-1726212-A | Pre-organized tricyclic integrase inhibitor compounds | GILEAD SCIENCES INC (US) | 2006-01-25 | — | — | CN | disclosed |
| CN-1046521-C | Preparation of derivative of 4-deoxcide-4-surface-podocyllin poison | TAIHO PHARMACEUTICAL CO LTD (JP) | 1999-11-17 | — | — | CN | disclosed |
| CN-1035821-C | Process for preparing 4-deoxy-4-epipodophyllotoxin derivatives | TAIHO PHARAMCEUTICAL CO LTD (JP) | 1997-09-10 | — | — | CN | disclosed |
| CN-1126723-A | Preparation of derivative of 4-deoxcide-4-surface-podocyllin poison | TAIHO PHARMACEUTICAL CO LTD (JP) | 1996-07-17 | — | — | CN | disclosed |
| CN-1064278-A | 4-deoxy-4-epipodophyllotoxin derivatives or pharmaceutically acceptable salts thereof | TAIHO PHARMACEUTICAL CO LTD (JP) | 1992-09-09 | — | — | CN | disclosed |