Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9787076 | 0.90 | POLB (0.74) | POLBKDM4ELMNAHTTMAPK1 | |
| SCHEMBL9855260 | 0.90 | PTGDR2 (0.68) | POLBKDM4ELMNAHTTMAPK1 | |
| SCHEMBL16092725 | 0.90 | MEN1 (0.61) | POLBKDM4ELMNAHTTMAPK1 | |
| SCHEMBL11056067 | 0.88 | POLB (0.71) | POLBKDM4ELMNAHTTMAPK1 | |
| SCHEMBL21665232 | 0.87 | NPC1 (0.73) | POLBKDM4ELMNAHTTMAPK1 | |
| SCHEMBL16090169 | 0.87 | POLB (0.63) | POLBKDM4ELMNAMAPK1ALDH1A1 | |
| SCHEMBL3224251 | 0.86 | NPC1 (0.81) | POLBKDM4ELMNAHTTMAPK1 | |
| SCHEMBL30205105 | 0.86 | NPC1 (0.81) | POLBKDM4ELMNAHTTMAPK1 | |
| SCHEMBL1114933 | 0.85 | POLB (0.64) | POLBKDM4ELMNAHTTMAPK1 | |
| SCHEMBL29260273 | 0.84 | POLB (0.67) | POLBKDM4ELMNAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263492-B1 | RETINOIDS, THEIR PREPARATION AND USE AS PHARMACEUTICAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | disclosed |
| US-4900478-A | SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-02-13 | — | — | US | disclosed |
| EP-0263492-A1 | Retinoids, their preparation and use as pharmaceutical compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1988-04-13 | — | — | EP | disclosed |
| US-4022908-A | Use of certain 2-nitro-3-phenyl-alkoxybenzofurans in inhibiting growth of microorganisms and intermediates in the synthesis of said benzofurans | RIKER LABORATORIES, INC. (US) | 1977-05-10 | — | — | US | disclosed |