Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9855785 | 0.97 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1FOLH1MRGPRX4PDE4A | |
| SCHEMBL9856081 | 0.97 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1FOLH1MRGPRX4PDE4A | |
| SCHEMBL9428150 | 0.88 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1FOLH1LTB4RHPGD | |
| SCHEMBL9428702 | 0.88 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1FOLH1LTB4RHPGD | |
| SCHEMBL9428678 | 0.88 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1FOLH1LTB4RHPGD | |
| SCHEMBL9428428 | 0.83 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1FOLH1NR1H4HPGD | |
| SCHEMBL9428048 | 0.79 | PTPN11 (0.46) | CYSLTR2CYSLTR1MRGPRX4LTB4RHPGD | |
| SCHEMBL9427799 | 0.77 | PTPN11 (0.47) | CYSLTR2CYSLTR1FOLH1MRGPRX4LTB4R | |
| SCHEMBL9429208 | 0.77 | PTPN11 (0.47) | CYSLTR2CYSLTR1MRGPRX4LTB4RHPGD | |
| SCHEMBL9429136 | 0.77 | CYSLTR2 (0.51) | CYSLTR2CYSLTR1FOLH1LTB4RHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296732-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-09 | — | — | EP | disclosed |
| EP-0296732-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1988-12-28 | — | — | EP | disclosed |