Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 9/20 | 0.92 |
| ▸ | HPGD | P15428 | 1/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL21715368 | 1.00 | TSHR (0.92) | TSHRHPGDALDH1A1CYP3A4ATM | |
| Hydrogen Peroxide SCHEMBL28268342 | 0.98 | TSHR (0.96) | TSHRHPGDALDH1A1CYP3A4ATM | |
| SCHEMBL1330627 | 0.96 | — | — | |
| SCHEMBL5681395 | 0.96 | TSHR (1.00) | TSHRHPGDALDH1A1CYP3A4ATM | |
| SCHEMBL15037 | 0.96 | — | — | |
| SCHEMBL11582291 | 0.96 | TSHR (1.00) | TSHRHPGDALDH1A1CYP3A4ATM | |
| SCHEMBL1331857 | 0.96 | — | — | |
| Benzene SCHEMBL25297827 | 0.94 | TSHR (0.88) | TSHRHPGDALDH1A1CYP3A4ATM | |
| Acetic Acid SCHEMBL1275660 | 0.94 | TSHR (0.88) | TSHRHPGDALDH1A1CYP3A4ATM | |
| Acrylic Acid SCHEMBL28508000 | 0.94 | TSHR (0.88) | TSHRHPGDALDH1A1CYP3A4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11401374-B2 | Poly (alkyl carbonate) adhesives | TRUSTEES OF BOSTON UNIVERSITY (US) | 2022-08-02 | — | — | US | disclosed |
| EP-0421666-A2 | Thermosetting resin composition | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1991-04-10 | — | — | EP | disclosed |