Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 7/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857813 | 0.77 | DHODH (0.37) | PTPN1MAP4K4DHODH | |
| SCHEMBL9857652 | 0.76 | PTPN1 (0.49) | MCL1PTPN1MAP4K4DHODH | |
| SCHEMBL2953824 | 0.75 | MEN1 (0.49) | PTGER1MCL1DHODH | |
| SCHEMBL9857871 | 0.75 | DHODH (0.50) | PTPN1DHODHFOLH1 | |
| SCHEMBL9857473 | 0.74 | DHODH (0.48) | PTPN1MAP4K4MAPTDHODH | |
| SCHEMBL31013973 | 0.73 | PTGER1 (0.51) | PTGER1MRGPRX4MCL1PTPN1LMNA | |
| SCHEMBL6592997 | 0.73 | MCL1 (0.51) | PTGER1MRGPRX4MCL1PTPN1MAP4K4 | |
| SCHEMBL1316077 | 0.73 | MCL1 (0.71) | PTGER1MRGPRX4MCL1PTPN1PTGER4 | |
| SCHEMBL16624212 | 0.72 | FFAR4 (0.62) | PTGER1MCL1MGLLGPR34LMNA | |
| SCHEMBL6245538 | 0.72 | PTGER1 (0.65) | PTGER1RXRARXRBRXRGMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5072023-A | Reacting lactone with ester anion to form cyclohexenone ester; oxidizing or dehydrogenating the intermediate | E. R. SQUIBB & SONS, INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0442495-A1 | Process for preparing highly substituted phenyls | E.R. SQUIBB & SONS, INC. (US) | 1991-08-21 | — | — | EP | disclosed |