SCHEMBL9862501

SCHEMBL9862501

O=C(O)CC(O)(Cn1cncn1)c1ccc(F)cc1F

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 16/20 0.79
CYP2C9 P11712 12/20 0.79
CYP2C19 P33261 12/20 0.79
LMNA P02545 2/20 0.79
HSP90AA1 P07900 1/20 0.79
CYP19A1 P11511 1/20 0.79
CYP11B1 P15538 1/20 0.79
CYP11B2 P19099 1/20 0.79
ADRA1A P35348 1/20 0.79
CYP51A1 Q16850 1/20 0.79
CYP2B6 P20813 1/20 0.52
CYP3A5 P20815 1/20 0.52
CYP3A7 P24462 1/20 0.52
MAPK1 P28482 1/20 0.52
CYP3A43 Q9HB55 1/20 0.52
CYP46A1 Q9Y6A2 1/20 0.52
HDAC3 O15379 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30944239 1.00 CYP3A4 (0.79) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL26094521 0.89 CYP3A4 (0.77) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL2326130 0.89 CYP3A4 (0.81) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL355326 0.89 CYP3A4 (0.95) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL29360276 0.89 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL3151 0.89 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL5597261 0.89 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL5503188 0.89 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL6378035 0.88 CYP3A4 (0.88) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL2244102 0.87 CYP3A4 (0.97) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5047548-A 3-aryl-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butyramide and derivatives as antifungal agents PFIZER INC. (US) 1991-09-10 US disclosed
EP-0106515-B1 TRIAZOLE ANTI-FUNGAL AGENTS Pfizer Limited (GB) 1988-12-28 EP disclosed
US-4503063-A PLANTS AND ANIMALS PFIZER INC. (US) 1985-03-05 US disclosed
EP-0106515-A2 Triazole anti-fungal agents Pfizer Limited (GB) 1984-04-25 EP disclosed