SCHEMBL9864193

SCHEMBL9864193

Cc1ccccc1N1CCc2nnc3c(C)cccc3c21

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.52
ALDH1A1 P00352 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9864388 0.84 DDB1 (0.42) KDM4E
Hydrochloric Acid SCHEMBL9864078 0.84 KDM4E (0.41) KDM4E
Hydrochloric Acid SCHEMBL2834772 0.77 KDM4E (0.79) KDM4EALDH1A1
SCHEMBL9684754 0.77 KDM4E (0.51) KDM4E
SCHEMBL9684654 0.76 KDM4E (0.66) KDM4EALDH1A1
SCHEMBL9684727 0.76 KDM4E (0.70) KDM4EALDH1A1
SCHEMBL9686119 0.73 KDM4E (0.62) KDM4EALDH1A1
SCHEMBL30862858 0.73 KDM4E (0.62) KDM4EALDH1A1
SCHEMBL29493309 0.73 KDM4E (0.62) KDM4EALDH1A1
SCHEMBL9685745 0.73 KDM4E (0.62) KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4988695-A Gastrointestinal disorders, antisecretory agents SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1991-01-29 US claimed
EP-0380257-A2 Condensed cinnoline derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) 1990-08-01 EP claimed
US-4988695-A Gastrointestinal disorders, antisecretory agents SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1991-01-29 US disclosed
EP-0380257-A2 Condensed cinnoline derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) 1990-08-01 EP disclosed