Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864271 | 0.89 | SLC6A4 (0.44) | SLC6A4SLC6A3SLC6A2KCNN4HTR2A | |
| SCHEMBL9864006 | 0.86 | SLC6A4 (0.43) | SLC6A4SLC6A3SLC6A2KCNN4HTR2A | |
| SCHEMBL9863817 | 0.85 | SLC6A4 (0.44) | SLC6A4SLC6A3SLC6A2KCNN4HTR2A | |
| Hydrochloric Acid SCHEMBL1521 | 0.81 | SLC6A4 (0.48) | SLC6A4SLC6A3SLC6A2KCNN4HTR2A | |
| SCHEMBL9864057 | 0.79 | SLC6A4 (0.43) | SLC6A4SLC6A3SLC6A2KCNN4HTR2A | |
| SCHEMBL9864213 | 0.75 | SLC6A4 (0.47) | SLC6A4SLC6A3SLC6A2KCNN4HTR2A | |
| SCHEMBL9864426 | 0.75 | CYP3A4 (0.59) | SLC6A4SLC6A3SLC6A2HTR2AHTR2B | |
| SCHEMBL9864324 | 0.73 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2KCNN4HTR2A | |
| SCHEMBL9863821 | 0.71 | SLC6A4 (0.43) | SLC6A4SLC6A3SLC6A2KCNN4KDM1A | |
| SCHEMBL9118387 | 0.71 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2KCNN4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |