SCHEMBL9864668

SCHEMBL9864668

N#Cc1ccc(CCCCCCC=O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.56
HSD17B10 Q99714 1/20 0.56
KCNJ1 P48048 2/20 0.43
KCNH2 Q12809 2/20 0.43
LOXL2 Q9Y4K0 2/20 0.42
CYP2A6 P11509 1/20 0.42
CA12 O43570 2/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA9 Q16790 2/20 0.40
CA4 P22748 1/20 0.40
DAO P14920 2/20 0.40
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
MMP12 P39900 1/20 0.38
MMP13 P45452 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
FAAH O00519 1/20 0.37
CYP19A1 P11511 4/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2260049 0.98 TSHR (0.53) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL20212772 0.95 TSHR (0.64) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL4864848 0.93 TSHR (0.50) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL2246626 0.85 KCNJ1 (0.48) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL16582463 0.84 TSHR (0.71) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL16582531 0.84 TSHR (0.71) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL10569117 0.84 TSHR (0.71) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL10569888 0.82 TSHR (0.68) TSHRHSD17B10KCNJ1KCNH2LOXL2
SCHEMBL27671362 0.80 HTR2B (0.44) KCNJ1KCNH2CYP11B1CYP11B2FAAH
SCHEMBL9457792 0.80 TSHR (0.53) TSHRHSD17B10KCNJ1KCNH2LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5011938-A Antimicrobials ELI LILLY AND COMPANY (US) 1991-04-30 US disclosed
US-4940718-A BACTERICIDES ELI LILLY AND COMPANY (US) 1990-07-10 US disclosed
US-4902707-A Bicyclic pyrazolidinones, compositions and use ELI LILLY AND COMPANY (US) 1990-02-20 US disclosed
US-4826992-A MICROBIOCIDE INTERMEDIATES ELI LILLY AND COMPANY (US) 1989-05-02 US disclosed
US-4795815-A BACTERICIDES, MICROBIOCIDES ELI LILLY AND COMPANY (US) 1989-01-03 US disclosed
EP-0203723-A1 2,3-(dihydro)bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-12-03 EP disclosed
EP-0203722-A1 Bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-12-03 EP disclosed
EP-0202794-A1 7-Substituted-2,3-(Dihydro) bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-11-26 EP disclosed
EP-0202046-A1 7-Substituted bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-11-20 EP disclosed
CN-86102877-A The method for preparing bicyclic pyrazolidinones 1986-10-29 CN disclosed
CN-85108623-A Preparation has the novel method of the heterocycleamide of medical active 1986-07-30 CN disclosed