Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867504 | 0.95 | HRH4 (0.40) | EBPSIGMAR1HRH4HRH3HRH2 | |
| SCHEMBL9877143 | 0.89 | HPGD (0.37) | EBPSIGMAR1HRH4HRH3HRH2 | |
| SCHEMBL9865989 | 0.87 | EBP (0.38) | EBPSIGMAR1HRH4HRH3 | |
| SCHEMBL9867202 | 0.84 | HRH4 (0.37) | EBPSIGMAR1HRH4HRH3HRH2 | |
| SCHEMBL9867357 | 0.83 | SCN5A (0.43) | HRH4HRH3 | |
| SCHEMBL9865960 | 0.83 | SCN5A (0.42) | HRH4HRH3 | |
| SCHEMBL9867126 | 0.83 | HRH4 (0.47) | HRH4HRH3HRH2 | |
| SCHEMBL9865440 | 0.83 | EBP (0.48) | EBPSIGMAR1HRH4HRH3HRH2 | |
| SCHEMBL9866256 | 0.82 | HRH4 (0.47) | HRH4HRH3HRH2 | |
| SCHEMBL9866660 | 0.82 | NPY1R (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |