Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | EBP | Q15125 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865287 | 1.00 | SCN5A (0.36) | SCN5ASCN2AHRH2RAB9ASMN1; SMN2 | |
| SCHEMBL9865291 | 0.93 | HRH2 (0.36) | SCN5ASCN2AHRH2HRH4 | |
| SCHEMBL9866696 | 0.89 | SCN5A (0.42) | SCN5ASCN2AHRH2RAB9ASMN1; SMN2 | |
| SCHEMBL9866702 | 0.89 | SCN5A (0.42) | SCN5ASCN2AHRH2RAB9ASMN1; SMN2 | |
| SCHEMBL9866987 | 0.86 | EBP (0.36) | SCN5ASCN2AHRH2RAB9ASMN1; SMN2 | |
| SCHEMBL7431296 | 0.86 | EPHX2 (0.41) | SCN5ASCN2AHRH2RAB9ANPC1 | |
| SCHEMBL7431291 | 0.86 | EPHX2 (0.41) | SCN5ASCN2AHRH2RAB9ANPC1 | |
| SCHEMBL9866763 | 0.85 | NPC1 (0.42) | SCN5ASCN2AHRH2RAB9ASMN1; SMN2 | |
| SCHEMBL9867435 | 0.85 | NPC1 (0.42) | SCN5ASCN2AHRH2RAB9ASMN1; SMN2 | |
| SCHEMBL9866135 | 0.85 | EPHX2 (0.41) | SCN5ASCN2AHRH2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |