⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12459955 | 1.00 | — | — | |
| SCHEMBL12409742 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL27036387 | 0.98 | IRAK4 (0.39) | — | |
| Hydrochloric Acid SCHEMBL30683992 | 0.98 | IRAK4 (0.39) | — | |
| SCHEMBL5991543 | 0.88 | IRAK4 (0.41) | — | |
| SCHEMBL14285588 | 0.88 | IRAK4 (0.41) | — | |
| SCHEMBL1715768 | 0.81 | — | — | |
| SCHEMBL21180014 | 0.80 | IRAK4 (0.39) | — | |
| SCHEMBL15727499 | 0.80 | IRAK4 (0.39) | — | |
| SCHEMBL23158355 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9770435-B2 | Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases | OGEDA SA (BE) | 2017-09-26 | — | — | US | disclosed |
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |
| WO-2017004610-A1 | TERCYCLIC S1P3-SPARING, S1P1 RECEPTOR AGONISTS | EXELIXIS, INC. (US) | 2017-01-05 | — | — | WO | disclosed |
| EP-2342191-B1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-03-20 | — | — | EP | disclosed |
| US-20110166135-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110166135-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-07-07 | — | — | US | disclosed |
| WO-2010052144-A2 | NEUROPEPTIDE-2-RECEPTOR (Y-2R) AGONISTS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010030027-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-18 | — | — | WO | disclosed |
| US-7314940-B2 | For therapy and prophylaxis of neurodegenerative disorders related to apoptosis and/or inflammation | EISAI CO., LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
| US-5066651-A | Sulfonyl group attached to nitrogen, Alzheimer*s disease, antihypoxic, antiischemic, memory lapses | ADIR ET COMPAGNIE (FR) | 1991-11-19 | — | — | US | disclosed |
| US-4999372-A | Cardiovascular, respiratory system, gastrointestinal, and urogenital disorders; stereoisomers | ADIR ET COMPAGNIE (FR) | 1991-03-12 | — | — | US | disclosed |