Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867092 | 0.97 | KDM4E (0.48) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL9867094 | 0.97 | KDM4E (0.48) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL9867607 | 0.96 | KDM4E (0.51) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL9867943 | 0.95 | KDM4E (0.47) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL9867603 | 0.95 | KDM4E (0.47) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL10371356 | 0.89 | ABCB1 (0.42) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL9866310 | 0.89 | ABCB1 (0.42) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL9866314 | 0.87 | KDM4E (0.43) | KDM4EALDH1A1 | |
| SCHEMBL10372224 | 0.86 | HRH2 (0.48) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL9865905 | 0.85 | NPC1 (0.46) | HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |