Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10746549 | 0.86 | KDM4E (0.51) | KDM4EMEN1KMT2APTGS1SRD5A1 | |
| SCHEMBL9867637 | 0.85 | KDM4E (0.42) | KDM4EMEN1KMT2APTGS1SRD5A1 | |
| SCHEMBL9867697 | 0.80 | CA12 (0.39) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9480791 | 0.79 | CA12 (0.40) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9866422 | 0.78 | POLB (0.39) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL28248424 | 0.73 | SRD5A1 (0.52) | KDM4EMEN1KMT2APTGS1SRD5A1 | |
| SCHEMBL9247111 | 0.72 | KDM4E (0.40) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL642836 | 0.71 | POLB (0.43) | KDM4EMEN1KMT2APTGS1POLB | |
| SCHEMBL10746532 | 0.71 | KDM4E (0.43) | KDM4EMEN1KMT2APTGS1SRD5A1 | |
| SCHEMBL19125185 | 0.70 | MAPT (0.43) | KDM4EMEN1KMT2APTGS1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | disclosed |