Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 6/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866485 | 0.96 | HRH4 (0.42) | HRH2HRH4KMT2ANPC1RAB9A | |
| SCHEMBL10369046 | 0.96 | HRH4 (0.42) | HRH2HRH4KMT2ANPC1RAB9A | |
| SCHEMBL9866766 | 0.95 | HRH2 (0.49) | HRH2HRH4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10369687 | 0.94 | TDP1 (0.39) | HRH2HRH4KMT2ANPC1RAB9A | |
| SCHEMBL10369686 | 0.94 | TDP1 (0.39) | HRH2HRH4KMT2ANPC1RAB9A | |
| SCHEMBL9865881 | 0.94 | HPGD (0.46) | HRH2HRH4KMT2ARAB9AHRH1 | |
| SCHEMBL9866763 | 0.94 | NPC1 (0.42) | HRH2HRH4KMT2ANPC1RAB9A | |
| SCHEMBL9867435 | 0.94 | NPC1 (0.42) | HRH2HRH4KMT2ANPC1RAB9A | |
| SCHEMBL9865867 | 0.90 | HPGD (0.46) | HRH2HRH4KMT2ANPC1RAB9A | |
| SCHEMBL9865876 | 0.90 | HPGD (0.46) | HRH2HRH4KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |