Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10814991 | 0.87 | BRD4 (0.48) | PARP1TDP1BRD4LMNA | |
| SCHEMBL10805151 | 0.86 | PARP1 (0.50) | PARP1TDP1BRD4 | |
| SCHEMBL9822840 | 0.85 | PARP1 (0.46) | PARP1TDP1BRD4 | |
| SCHEMBL9867437 | 0.84 | PARP1 (0.45) | PARP1TDP1BRD4LMNA | |
| SCHEMBL10805415 | 0.84 | PARP1 (0.45) | PARP1TDP1BRD4 | |
| SCHEMBL10810657 | 0.83 | PARP1 (0.42) | PARP1 | |
| SCHEMBL9868369 | 0.81 | PARP1 (0.42) | PARP1TDP1BRD4 | |
| SCHEMBL7439696 | 0.80 | PARP1 (0.51) | PARP1TDP1 | |
| SCHEMBL8939924 | 0.78 | PARP1 (0.52) | PARP1TDP1LMNA | |
| SCHEMBL7126040 | 0.77 | PARP1 (0.49) | PARP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | disclosed |