Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 9/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 7/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985539 | 0.87 | KCNN4 (0.41) | MAP4K4KCNN4ACHE | |
| SCHEMBL986961 | 0.84 | MAP4K4 (0.41) | MAP4K4KCNN4ACHEKCNH2 | |
| SCHEMBL27900688 | 0.84 | KCNN4 (0.40) | MAP4K4KCNN4ACHECHEK2MKNK1 | |
| SCHEMBL982610 | 0.83 | MAP4K4 (0.44) | MAP4K4KCNN4ACHEKCNH2 | |
| SCHEMBL988095 | 0.83 | CHEK2 (0.42) | MAP4K4KCNN4ACHECHEK2MKNK1 | |
| SCHEMBL985174 | 0.82 | KCNN4 (0.45) | MAP4K4KCNN4ACHE | |
| SCHEMBL984679 | 0.82 | KCNN4 (0.39) | MAP4K4KCNN4ACHE | |
| SCHEMBL986230 | 0.82 | KCNN4 (0.49) | MAP4K4KCNN4ACHE | |
| SCHEMBL987882 | 0.82 | MAPT (0.40) | MAP4K4KCNN4ACHECHEK2 | |
| SCHEMBL982754 | 0.82 | CHEK2 (0.53) | MAP4K4CHEK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872031-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-18 | — | — | US | claimed |