Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 18/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870949 | 1.00 | GCGR (0.56) | GCGRDPP4DPP8DPP9ESR1 | |
| SCHEMBL9871037 | 0.84 | GCGR (0.52) | GCGR | |
| SCHEMBL9871041 | 0.84 | GCGR (0.52) | GCGR | |
| SCHEMBL2651071 | 0.82 | GCGR (0.56) | GCGRDPP4DPP8DPP9 | |
| SCHEMBL2647594 | 0.80 | GCGR (0.70) | GCGR | |
| SCHEMBL2646545 | 0.76 | GCGR (0.77) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL5098308 | 0.76 | GCGR (0.50) | GCGRDPP4DPP8DPP9 | |
| SCHEMBL8879628 | 0.75 | DHODH (0.55) | GCGRDPP4DPP8DPP9 | |
| SCHEMBL27293870 | 0.75 | GCGR (0.49) | GCGRDPP4DPP8DPP9 | |
| SCHEMBL9870958 | 0.74 | GCGR (0.72) | GCGRDPP4DPP8DPP9ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997837-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4906624-A | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |