Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.45 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752624 | 0.98 | PDE4B (0.45) | PDE4BPDE4DTOP2AKDM4EKMT2A | |
| SCHEMBL9879251 | 0.93 | PDE4B (0.42) | PDE4BPDE4DTOP2ARAD52 | |
| SCHEMBL8576941 | 0.89 | PDE4B (0.44) | PDE4BPDE4DTOP2A | |
| SCHEMBL9752708 | 0.83 | PDE4B (0.44) | PDE4BPDE4DKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9752508 | 0.82 | PDE4B (0.43) | PDE4BPDE4DKMT2AMEN1 | |
| SCHEMBL9752566 | 0.81 | PDE4B (0.58) | PDE4BPDE4D | |
| SCHEMBL9871473 | 0.81 | PDE4B (0.55) | PDE4BPDE4D | |
| SCHEMBL9752995 | 0.81 | PDE4B (0.60) | PDE4BPDE4D | |
| SCHEMBL9870693 | 0.81 | PDE4B (0.58) | PDE4BPDE4D | |
| SCHEMBL9872416 | 0.80 | PDE4B (0.59) | PDE4BPDE4DKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | disclosed |