Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30681912 | 0.98 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL7913301 | 0.98 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL26618036 | 0.98 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL24517228 | 0.97 | KDM4E (0.47) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL29378235 | 0.97 | KDM4E (0.47) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL2899648 | 0.84 | KDM4E (0.71) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL10472947 | 0.83 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL31345641 | 0.83 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL26617810 | 0.83 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL2897233 | 0.83 | KDM4E (0.70) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119585247-A | Bicyclic heterocyclic amide inhibitors of nav1.8 for the treatment of pain | 赛特温治疗公司 | 2025-03-07 | — | — | CN | disclosed |
| EP-4514789-A1 | <SUP2/>? <SUB2/>?V?BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA1.8 FOR THE TREATMENT OF PAIN | SiteOne Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| US-4987232-A | ONE POT, GOOD YIELD | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ, B.V. (NL) | 1991-01-22 | — | — | US | disclosed |
| EP-0372654-A2 | Preparation of 2-chloropyridine 3-carboxylic acid esters | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-06-13 | — | — | EP | disclosed |