Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 9/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870592 | 0.84 | HMGCR (0.69) | HMGCR | |
| SCHEMBL9870588 | 0.84 | HMGCR (0.69) | HMGCR | |
| SCHEMBL9872007 | 0.82 | HMGCR (0.66) | HMGCR | |
| SCHEMBL9872037 | 0.80 | HMGCR (0.70) | HMGCR | |
| SCHEMBL9872024 | 0.80 | HMGCR (0.70) | HMGCR | |
| SCHEMBL10398500 | 0.78 | HMGCR (0.77) | HMGCR | |
| SCHEMBL10900205 | 0.76 | HMGCR (0.62) | HMGCR | |
| SCHEMBL10468182 | 0.75 | HMGCR (0.62) | HMGCR | |
| SCHEMBL9870214 | 0.75 | HMGCR (0.62) | HMGCR | |
| SCHEMBL10475420 | 0.75 | HMGCR (0.59) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997837-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4906624-A | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0306929-A2 | 6-[[(Substituted)pyridin-3-YL]alkyl]-and alkenyl]-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1989-03-15 | — | — | EP | disclosed |