SCHEMBL9872018

SCHEMBL9872018

Cc1ccc(S(=O)(=O)n2c3c(c4ccccc42)C(=O)C(Cn2ccnc2C)CS3)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.51
KCNH2 Q12809 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
HTR3E A5X5Y0 1/20 0.51
SLC22A2 O15244 1/20 0.51
SLC22A1 O15245 1/20 0.51
SLC22A3 O75751 1/20 0.51
HTR3B O95264 1/20 0.51
CHRNB2 P17787 1/20 0.51
CHRNB4 P30926 1/20 0.51
CHRNA3 P32297 1/20 0.51
HTR2B P41595 1/20 0.51
CHRNA4 P43681 1/20 0.51
HTR3A P46098 1/20 0.51
HTR3D Q70Z44 1/20 0.51
SLC47A2 Q86VL8 1/20 0.51
HTR3C Q8WXA8 1/20 0.51
SLC47A1 Q96FL8 1/20 0.51
PCSK9 Q8NBP7 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9871585 0.88 KCNH2 (0.55) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
SCHEMBL9747308 0.83 CYP3A4 (0.69) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
SCHEMBL9372685 0.82 CYP3A4 (0.67) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
SCHEMBL10660144 0.78 CYP3A4 (0.45) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
Fumaric Acid SCHEMBL10660147 0.78 CYP3A4 (0.61) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
Maleic Acid SCHEMBL10660135 0.78 CYP3A4 (0.61) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
SCHEMBL9369470 0.73 CYP3A4 (0.70) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
SCHEMBL9744695 0.72 CYP3A4 (0.75) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
SCHEMBL9872754 0.72 CYP3A4 (0.53) CYP3A4KCNH2CYP1A2CYP2D6HTR3E
SCHEMBL9872448 0.72 KCNH2 (0.50) CYP3A4KCNH2CYP1A2CYP2D6HTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5030646-A Treatment of diseases resulting from disfunction of seretoninergic system ADIR ET COMPAGNIE (FR) 1991-07-09 US disclosed