Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.83 |
| ▸ | KLK7 | P49862 | 2/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30872637 | 0.96 | PREP (0.77) | PREPKLK7KLK5NPSR1MEN1 | |
| SCHEMBL9872222 | 0.91 | PREP (1.00) | PREPKLK7KLK5NPSR1KMT2A | |
| SCHEMBL15817600 | 0.82 | PREP (0.58) | PREPKLK7KLK5NPSR1MEN1 | |
| SCHEMBL20653871 | 0.82 | PREP (0.61) | PREPKLK7KLK5NPSR1MEN1 | |
| SCHEMBL20654187 | 0.82 | PREP (0.61) | PREPKLK7KLK5NPSR1MEN1 | |
| SCHEMBL31323701 | 0.81 | PREP (0.57) | PREPKLK7KLK5NPSR1MEN1 | |
| SCHEMBL5940389 | 0.80 | PREP (0.59) | PREPKLK7KLK5NPSR1MEN1 | |
| SCHEMBL5940103 | 0.80 | PREP (0.59) | PREPKLK7KLK5NPSR1MEN1 | |
| SCHEMBL3049973 | 0.80 | PREP (0.58) | PREPKLK7KLK5NPSR1KMT2A | |
| SCHEMBL6358373 | 0.79 | PREP (0.57) | PREPKLK7KLK5NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051444-A | Pyrrolidine derivatives as anti-amnesia agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1991-09-24 | — | — | US | disclosed |
| US-4880827-A | Pyrrolidine derivatives having inhibitory action for proline specific endopepidase | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0238319-A1 | Pyrrolidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-09-23 | — | — | EP | disclosed |