Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F13A1 | P00488 | 3/20 | 0.49 |
| ▸ | TGM2 | P21980 | 3/20 | 0.49 |
| ▸ | TGM1 | P22735 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17633253 | 1.00 | F13A1 (0.49) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL24136459 | 1.00 | F13A1 (0.49) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL20983428 | 1.00 | F13A1 (0.49) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL17633251 | 1.00 | F13A1 (0.49) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL17633250 | 1.00 | F13A1 (0.49) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL18592896 | 0.91 | SMN1; SMN2 (0.53) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL13567846 | 0.85 | SMN1; SMN2 (0.52) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL3628114 | 0.84 | SMN1; SMN2 (0.60) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL12836007 | 0.84 | SMN1; SMN2 (0.60) | F13A1TGM2TGM1SMN1; SMN2NPC1 | |
| SCHEMBL31459972 | 0.84 | F13A1 (0.48) | F13A1TGM2TGM1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3683207-B1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | CADENT THERAPEUTICS INC (US) | 2021-12-29 | — | — | EP | disclosed |
| US-20200369610-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | CADENT THERAPEUTICS, INC. (US) | 2020-11-26 | — | — | US | disclosed |
| US-10781174-B2 | N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[C]pyrrole negative allosteric modulators of NR2B | CADENT THERAPEUTICS, INC. (US) | 2020-09-22 | — | — | US | disclosed |
| US-20190152912-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | CADENT THERAPEUTICS, INC. (US) | 2019-05-23 | — | — | US | disclosed |
| US-10239835-B2 | N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of NR2B | CADENT THERAPEUTICS, INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180111902-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | LUC THERAPEUTICS, INC. (US) | 2018-04-26 | — | — | US | disclosed |
| US-20180111902-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | LUC THERAPEUTICS, INC. (US) | 2018-04-26 | — | — | US | disclosed |
| WO-2016049165-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | MNEMOSYNE PHARMACEUTICALS, INC. (US) | 2016-03-31 | — | — | WO | disclosed |
| US-5017708-A | Azabicycloalkanes | SHIONOGI & CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0359172-A1 | Azabicycloalkanes | SHIONOGI & CO., LTD. (JP) | 1990-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10781174-B2 | N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[C]pyrrole negative allosteric modulators of NR2B | GRIN2A, GRIN2C, GRIN3A | F13A1 3397/4885TGM2 3318/4885TGM1 2922/4885 |
| US-20200369610-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | GRIN2A, GRIN2C, GRIN3A | F13A1 3397/4885TGM2 3318/4885TGM1 2922/4885 |
| US-20180111902-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | OXER1, OPRL1, OXGR1 | F13A1 3393/4885TGM2 4443/4885TGM1 4216/4885 |
| US-10239835-B2 | N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of NR2B | OXER1, OPRL1, OXGR1 | F13A1 3393/4885TGM2 4443/4885TGM1 4216/4885 |
| US-20190152912-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | GRIN2A, GRIN2C, GRIN3A | F13A1 3397/4885TGM2 3318/4885TGM1 2922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.