Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.62 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876052 | 0.87 | MEN1 (0.49) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8667072 | 0.87 | KCNH2 (0.80) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL9875273 | 0.87 | KCNH2 (0.79) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL6784057 | 0.83 | KCNH2 (0.66) | KCNH2POLBMEN1KMT2AKDM4E | |
| SCHEMBL10777266 | 0.83 | MEN1 (0.55) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL1344898 | 0.82 | STAT3 (0.54) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9875522 | 0.81 | KCNH2 (0.60) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL12156452 | 0.81 | KCNH2 (0.70) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL13925384 | 0.81 | KCNH2 (0.70) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9837304 | 0.81 | KCNH2 (0.69) | KCNH2POLBCACNA1FMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221463-B1 | QUINOLINE DERIVATIVES AND PROCESSES FOR PREPARATION THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4795751-A | 5-substituted-6,8-difluoroquinolines useful as antibacterial agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-01-03 | — | — | US | disclosed |
| EP-0221463-A2 | Quinoline derivatives and processes for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-05-13 | — | — | EP | disclosed |