Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ipazilide SCHEMBL635854 | 0.80 | MAPK1 (0.55) | MEN1KMT2AMAPK1GAAPOLB | |
| SCHEMBL9877262 | 0.79 | KDM4E (0.48) | MEN1KMT2AMAPK1GAAITGB3 | |
| Ipazilide SCHEMBL9877353 | 0.79 | MAPK1 (0.54) | MEN1KMT2AMAPK1GAAPOLB | |
| SCHEMBL10359075 | 0.78 | MEN1 (0.64) | MEN1KMT2AMAPK1GAAPOLB | |
| Water SCHEMBL10510762 | 0.78 | MEN1 (0.63) | MEN1KMT2AMAPK1GAAPOLB | |
| SCHEMBL10358746 | 0.76 | TP53 (0.52) | MEN1KMT2AMAPK1GAAPOLB | |
| Ipazilide SCHEMBL120491 | 0.76 | MAPK1 (0.51) | MEN1KMT2AMAPK1GAAPOLB | |
| SCHEMBL9877376 | 0.76 | MAPK1 (0.51) | MEN1KMT2AMAPK1GAAPOLB | |
| SCHEMBL9878032 | 0.76 | MAPK1 (0.51) | MEN1KMT2AMAPK1GAAPOLB | |
| Ipazilide SCHEMBL120490 | 0.76 | MAPK1 (0.51) | MEN1KMT2AMAPK1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |