Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PTGIR | P43119 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877095 | 0.90 | SMN1; SMN2 (0.76) | SMN1; SMN2S1PR1TSHRALDH1A1POLB | |
| SCHEMBL9877279 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2S1PR1TSHRALDH1A1HTT | |
| SCHEMBL9878548 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2S1PR1TSHRALDH1A1HTT | |
| SCHEMBL9877275 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2S1PR1TSHRALDH1A1POLB | |
| SCHEMBL9877383 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2S1PR1TSHRALDH1A1POLB | |
| SCHEMBL5836730 | 0.83 | MAPK14 (0.56) | SMN1; SMN2S1PR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL10557065 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2S1PR1TSHRALDH1A1POLB | |
| SCHEMBL9877360 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2S1PR1TSHRALDH1A1POLB | |
| SCHEMBL10414084 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2S1PR1TSHRALDH1A1POLB | |
| SCHEMBL10401498 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2S1PR1TSHRALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0299407-B1 | 1H-PYRAZOLE-1-ALKANAMIDES AND PREPARATION USEFUL AS ANTIARRHYTHMIC AGENTS | STERLING DRUG INC. (US) | 1990-10-24 | — | — | EP | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |
| US-4870095-A | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use | STERLING DRUG, INC. (US) | 1989-09-26 | — | — | US | disclosed |
| EP-0299407-A1 | 1H-pyrazole-1-alkanamides and preparation useful as antiarrhythmic agents | STERLING DRUG INC. (US) | 1989-01-18 | — | — | EP | disclosed |