Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.54 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099186 | 0.93 | DPP8 (0.56) | DPP8DPP9TGM2ALDH1A1MAPT | |
| SCHEMBL10500161 | 0.91 | DPP8 (0.58) | DPP8DPP9TGM2ALDH1A1MAPT | |
| SCHEMBL9877714 | 0.89 | DPP8 (0.52) | DPP8DPP9TGM2ALDH1A1MAPT | |
| SCHEMBL11161416 | 0.87 | DPP8 (0.55) | DPP8DPP9TGM2ALDH1A1MAPT | |
| SCHEMBL10825508 | 0.86 | DPP8 (0.54) | DPP8DPP9TGM2ALDH1A1MAPT | |
| SCHEMBL6397529 | 0.86 | DPP8 (0.54) | DPP8DPP9TGM2ALDH1A1MAPT | |
| SCHEMBL10916785 | 0.86 | DPP8 (0.54) | DPP8DPP9TGM2ALDH1A1MAPT | |
| SCHEMBL9128787 | 0.86 | DPP8 (0.54) | DPP8DPP9TGM2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5724600 | 0.84 | DPP8 (0.55) | DPP8DPP9TGM2ALDH1A1MAPT | |
| SCHEMBL6418689 | 0.84 | DPP8 (0.58) | DPP8DPP9TGM2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992542-A | Thienamycin antibiotics | MERCK & CO., INC. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0001628-B1 | 3-SUBSTITUTED-6-SUBSTITUTED-7-OXO-1-AZABICYCLO (3.2.0)-HEPT-2-ENE-2-CARBOXYLIC ACID, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | MERCK & CO. INC. (US) | 1984-01-18 | — | — | EP | disclosed |
| EP-0010317-B1 | 6-, 1- AND 2-SUBSTITUTED-1-CARBAPEN-2-EM-3-CARBOXYLIC ACIDS, PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION COMPRISING SUCH COMPOUNDS | MERCK & CO. INC. (US) | 1983-12-21 | — | — | EP | disclosed |
| EP-0082133-A2 | A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids | MERCK & CO. INC. (US) | 1983-06-22 | — | — | EP | disclosed |
| US-4347368-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4281002-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1981-07-28 | — | — | US | disclosed |
| US-4269873-A | PENICILLIN DERIVATIVES | MERCK & CO., INC. (US) | 1981-05-26 | — | — | US | disclosed |
| US-4264621-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1981-04-28 | — | — | US | disclosed |
| US-4234596-A | ISOMERS OF THIENAMYCIN | MERCK & CO., INC. (US) | 1980-11-18 | — | — | US | disclosed |
| US-4232036-A | 6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids | MERCK & CO., INC. (US) | 1980-11-04 | — | — | US | disclosed |
| EP-0017992-A1 | 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates | MERCK & CO. INC. (US) | 1980-10-29 | — | — | EP | disclosed |
| US-4224336-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4218462-A | 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1-substituted-1-carbade-thiapen-2-em-3-carboxylic acids | MERCK & CO., INC. (US) | 1980-08-19 | — | — | US | disclosed |
| EP-0010317-A1 | 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds | MERCK & CO. INC. (US) | 1980-04-30 | — | — | EP | disclosed |
| EP-0001628-A1 | 3-Substituted-6-substituted-7-oxo-1-azabicyclo (3.2.0)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it | MERCK & CO. INC. (US) | 1979-05-02 | — | — | EP | disclosed |