Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347072 | 0.98 | GSK3B (0.59) | GSK3BCES2CES1DAONPSR1 | |
| SCHEMBL9879032 | 0.95 | GSK3B (0.56) | GSK3BCES2CES1DAONPSR1 | |
| SCHEMBL4059184 | 0.85 | GSK3B (0.56) | GSK3BCES2CES1DAONPSR1 | |
| SCHEMBL490430 | 0.83 | GSK3B (0.54) | GSK3BCES2CES1DAONPSR1 | |
| SCHEMBL3471710 | 0.81 | GSK3B (0.56) | GSK3BCES2CES1DAONPSR1 | |
| SCHEMBL14624168 | 0.80 | GSK3B (0.63) | GSK3BCES2CES1DAONPSR1 | |
| SCHEMBL14624174 | 0.80 | GSK3B (0.54) | GSK3BCES2CES1DAONPSR1 | |
| SCHEMBL6781684 | 0.79 | DAO (0.52) | DAOGAAKDM4EPOLBCASP3 | |
| SCHEMBL7902938 | 0.77 | HPGD (0.38) | GSK3BNPSR1GAAKDM4EKMT2A | |
| SCHEMBL15686222 | 0.77 | GSK3B (0.59) | GSK3BCES2CES1DAONPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| WO-1989008651-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |