⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427328 | 1.00 | — | — | |
| SCHEMBL42216 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL10488738 | 0.95 | — | — | |
| SCHEMBL9215337 | 0.73 | — | — | |
| SCHEMBL5932438 | 0.73 | — | — | |
| SCHEMBL5932292 | 0.70 | — | — | |
| SCHEMBL269974 | 0.70 | — | — | |
| SCHEMBL566852 | 0.70 | — | — | |
| SCHEMBL567526 | 0.70 | — | — | |
| SCHEMBL106820 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165285-A1 | COMBINED PREPARATION FOR USE AS A MEDICAMENT | CBT DEVELOPMENT LIMITED (GB) | 2012-06-28 | — | — | US | claimed |
| EP-2451456-A1 | COMBINED PREPARATION FOR USE AS A MEDICAMENT | CBT Development Limited (GB) | 2012-05-16 | — | — | EP | claimed |
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | claimed |
| WO-2011004166-A1 | COMBINED PREPARATION FOR USE AS A MEDICAMENT | CBT DEVELOPMENT LIMITED (GB) | 2011-01-13 | — | — | WO | claimed |
| EP-2074120-B1 | TROPANE COMPOUNDS | EXELIXIS INC (US) | 2010-03-03 | — | — | EP | claimed |
| EP-2081946-A2 | ADENOSINE DERIVATIVES FOR THE TREATMENT OF PAIN | Biovitrum AB (publ) (SE) | 2009-07-29 | — | — | EP | claimed |
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | claimed |
| US-7482356-B2 | Bicyclic pyrazolone cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2009-01-27 | — | — | US | claimed |
| US-20080221060-A1 | Adenosine derivatives for treatment of pain and/or inflammation; diabetes | BIOVITRUM AB (PUBL) (SE) | 2008-09-11 | — | — | US | claimed |
| US-20080076776-A1 | Therapeutic compounds | BIOVITRUM AB (SE) | 2008-03-27 | — | — | US | claimed |
| WO-2008000745-A2 | ADENOSINE DERIVATIVES FOR THE TREATMENT OF PAIN | BIOVITRUM AB (PUBL) (SE) | 2008-01-03 | — | — | WO | claimed |
| EP-1749016-A2 | ADENOSINE RECEPTOR AGONISTS | Cambridge Biotechnology Ltd (GB) | 2007-02-07 | — | — | EP | claimed |
| WO-2005084653-A2 | ADENOSINE RECEPTOR AGONISTS | CAMBRIDGE BIOTECHNOLOGY LIMITED (GB) | 2005-09-15 | — | — | WO | claimed |
| US-20050113392-A1 | Bicyclic pyrazolone cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2005-05-26 | — | — | US | claimed |
| US-6677337-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, CACHEXIA, SEPTIC SHOCK, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | THE PROCTER & GAMBLE COMPANY | 2004-01-13 | — | — | US | claimed |
| US-20120165285-A1 | COMBINED PREPARATION FOR USE AS A MEDICAMENT | CBT DEVELOPMENT LIMITED (GB) | 2012-06-28 | — | — | US | disclosed |
| EP-2081946-B1 | ADENOSINE DERIVATIVES FOR THE TREATMENT OF PAIN | CBT DEV LTD (GB) | 2012-05-30 | — | — | EP | disclosed |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2003-07-17 | — | — | US | disclosed |
| US-20030105084-A1 | Compound which inhibit the release of inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2003-06-05 | — | — | US | disclosed |
| US-6566357-B1 | To inhibit the extracellular release of inflammatory cytokines; therapy | THE PROCTER & GAMBLE CO. | 2003-05-20 | — | — | US | disclosed |