Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876328 | 0.89 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9876327 | 0.89 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7276125 | 0.88 | PDE3B (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7276028 | 0.87 | PDE3B (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7267008 | 0.86 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7267004 | 0.86 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7269474 | 0.86 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7267327 | 0.86 | PDE3B (0.49) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7273763 | 0.84 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7269335 | 0.83 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051417-A | Indolythiadiazines for treating heart failure | LES LABORATOIRES BEECHAM S.A. (FR) | 1991-09-24 | — | — | US | claimed |