Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 4/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | ENTPD5 | O75356 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9883110 | 0.89 | PIK3CB (0.51) | PIK3CBPIK3CAPIK3CGKIF11LTB4R | |
| SCHEMBL9880749 | 0.87 | PIK3CB (0.48) | PIK3CBPIK3CAPIK3CGKIF11LTB4R | |
| SCHEMBL9880764 | 0.86 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CGKIF11LTB4R | |
| SCHEMBL9880768 | 0.86 | PIK3CB (0.56) | PIK3CBPIK3CAPIK3CGKIF11LTB4R | |
| SCHEMBL9880782 | 0.81 | PIK3CA (0.46) | PIK3CBPIK3CAPIK3CGLTB4RALOX15 | |
| SCHEMBL9880757 | 0.81 | PIK3CB (0.72) | PIK3CBPIK3CAPIK3CGKIF11LTB4R | |
| SCHEMBL12234384 | 0.79 | PIK3CB (0.57) | PIK3CBPIK3CAPIK3CGKIF11LTB4R | |
| SCHEMBL9883108 | 0.77 | PIK3CB (0.47) | PIK3CBPIK3CAPIK3CGKIF11LTB4R | |
| SCHEMBL14196106 | 0.76 | PIK3CB (0.57) | PIK3CBPIK3CAPIK3CGKIF11LTB4R | |
| SCHEMBL9883107 | 0.75 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CGKIF11LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765994-B2 | Ship 1 modulators | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-07-01 | — | — | US | disclosed |
| US-20120129925-A1 | SHIP 1 MODULATORS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129925-A1 | SHIP 1 MODULATORS | PPP1R10, SACM1L, PPP1R1B | PIK3CB 62/4885PIK3CA 131/4885PIK3CG 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.