Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 2/20 | 0.78 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.38 |
| ▸ | ENTPD5 | O75356 | 1/20 | 0.37 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.37 |
| ▸ | FDPS | P14324 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pelorol SCHEMBL12234334 | 1.00 | PIK3CB (0.78) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 | |
| Pelorol SCHEMBL384771 | 1.00 | PIK3CB (0.78) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 | |
| Pelorol SCHEMBL12234332 | 1.00 | PIK3CB (0.78) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 | |
| SCHEMBL15849077 | 0.91 | PIK3CB (0.64) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 | |
| SCHEMBL9880780 | 0.91 | PIK3CB (0.64) | PIK3CBPIK3CAPIK3CGGGPS1FDPS | |
| SCHEMBL9880765 | 0.88 | PIK3CB (1.00) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 | |
| SCHEMBL14196106 | 0.85 | PIK3CB (0.57) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 | |
| SCHEMBL15849820 | 0.83 | PIK3CB (0.55) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 | |
| SCHEMBL9880757 | 0.81 | PIK3CB (0.72) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 | |
| SCHEMBL9880746 | 0.81 | PIK3CB (0.71) | PIK3CBIDO1PIK3CAPIK3CGENTPD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765994-B2 | Ship 1 modulators | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-07-01 | — | — | US | disclosed |
| US-8765994-B2 | Ship 1 modulators | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-07-01 | — | — | US | disclosed |
| US-20120129925-A1 | SHIP 1 MODULATORS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-05-24 | — | — | US | disclosed |
| US-20120129925-A1 | SHIP 1 MODULATORS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-05-24 | — | — | US | disclosed |
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2011-10-27 | — | — | US | disclosed |
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2011-10-27 | — | — | US | disclosed |
| US-20100323990-A1 | SHIP 1 MODULATOR PRODRUGS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2010-12-23 | — | — | US | disclosed |
| US-20100323990-A1 | SHIP 1 MODULATOR PRODRUGS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2010-12-23 | — | — | US | disclosed |
| US-20080090909-A1 | negative regulator of cell growth factor receptor; pelorol (benzo(a)fluorene) related compounds from marine sponge species; antiinflammatory, antitumor agent, immunostimulant; control gene expression, differentiation, metabolism, phospholipid signaling pathway, signal tansduction | THE UNIVERSITY OF BRITISH COLUMBIA | 2008-04-17 | — | — | US | disclosed |
| US-20080090909-A1 | negative regulator of cell growth factor receptor; pelorol (benzo(a)fluorene) related compounds from marine sponge species; antiinflammatory, antitumor agent, immunostimulant; control gene expression, differentiation, metabolism, phospholipid signaling pathway, signal tansduction | THE UNIVERSITY OF BRITISH COLUMBIA | 2008-04-17 | — | — | US | disclosed |
| WO-2007147252-A1 | SHIP 1 MODULATOR PRODRUGS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007147251-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100323990-A1 | SHIP 1 MODULATOR PRODRUGS | PPM1D, PPM1G, PPM1F | PIK3CB 74/4885IDO1 248/4885PIK3CA 94/4885 |
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | PPM1F, PPM1D, PPP1R1B | PIK3CB 87/4885IDO1 800/4885PIK3CA 146/4885 |
| US-20080090909-A1 | negative regulator of cell growth factor receptor; pelorol (benzo(a)fluorene) related compounds from marine sponge species; antiinflammatory, antitumor agent, immunostimulant; control gene expression, differentiation, metabolism, phospholipid signaling pathway, signal tansduction | STAT1, STING1, IRF3 | PIK3CB 215/4885IDO1 996/4885PIK3CA 200/4885 |
| US-20120129925-A1 | SHIP 1 MODULATORS | PPP1R10, SACM1L, PPP1R1B | PIK3CB 62/4885IDO1 3237/4885PIK3CA 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.