Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 8/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.40 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9882269 | 1.00 | PIM1 (0.46) | PIM1PTPN11PRKCQPRKCDPRKCA | |
| SCHEMBL9882234 | 0.94 | PIM1 (0.49) | PIM1PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882300 | 0.94 | PIM1 (0.49) | PIM1PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882289 | 0.94 | PIM1 (0.49) | PIM1PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882249 | 0.94 | PIM1 (0.53) | PIM1PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882316 | 0.90 | PRKCQ (0.44) | PIM1PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882101 | 0.88 | PRKCQ (0.53) | PIM1PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882102 | 0.88 | PRKCQ (0.53) | PIM1PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882075 | 0.88 | PTPN11 (0.46) | PIM1PTPN11PRKCQPRKCDPRKCA | |
| SCHEMBL9882250 | 0.88 | PRKCQ (0.43) | PIM1PRKCQPRKCDPRKCAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136000-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136000-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | MAP3K20, MAP3K5, PRKACA | PIM1 305/4885PTPN11 775/4885PRKCQ 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.