Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18879420 | 0.94 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL9884352 | 0.91 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL18708650 | 0.89 | PIK3CD (0.71) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL22215365 | 0.87 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL957120 | 0.86 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL957122 | 0.86 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL9884150 | 0.86 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL957556 | 0.86 | PIK3CD (0.69) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL9884081 | 0.86 | PIK3CG (0.69) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL958791 | 0.86 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245169-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | INTELLIKINE LLC | 2012-09-27 | — | — | US | disclosed |
| US-20120149701-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | INTELLIKINE, INC. | 2012-06-14 | — | — | US | disclosed |
| US-8193182-B2 | Substituted isoquinolin-1(2H)-ones, and methods of use thereof | INTELLIKINE, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20110046165-A1 | CERTAIN CHEMICAL ENTITLES, COMPOSITIONS AND METHODS | INTELLIKINE LLC | 2011-02-24 | — | — | US | disclosed |
| US-20090312319-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | INTELLIKINE | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312319-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | PIK3CA, PIK3CG, PIK3CB | PIK3CD 4/4885PIK3CG 2/4885PIK3CB 3/4885 |
| US-20120245169-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | PIK3CA, PIK3CG, PIK3CB | PIK3CD 4/4885PIK3CG 2/4885PIK3CB 3/4885 |
| US-20120149701-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | PIK3CA, AKT3, PIK3C2A | PIK3CD 7/4885PIK3CG 8/4885PIK3CB 4/4885 |
| US-20110046165-A1 | CERTAIN CHEMICAL ENTITLES, COMPOSITIONS AND METHODS | PIK3CA, AKT3, PIK3C2A | PIK3CD 6/4885PIK3CG 15/4885PIK3CB 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.