Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.58 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990173 | 0.90 | PIK3CA (0.71) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL12535591 | 0.86 | PIK3CA (0.72) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL12535571 | 0.83 | PIK3CA (0.82) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL988745 | 0.83 | PIK3CA (0.79) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL989584 | 0.78 | PIK3CA (0.44) | PIK3CAPIK3C3PIK3CBMAPK14 | |
| SCHEMBL12535587 | 0.77 | PIK3CA (0.69) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL12535601 | 0.75 | PIK3CA (0.88) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL13650131 | 0.74 | PIK3CA (0.76) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL11967366 | 0.74 | PIK3CA (0.67) | PIK3CAPIK3C3PIK3CDPIK3CG | |
| SCHEMBL12535640 | 0.73 | PIK3CA (0.78) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |