Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.63 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.58 |
| ▸ | TNKS | O95271 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.58 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.58 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.58 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.58 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.58 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.58 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.58 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.58 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.58 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22971687 | 0.92 | PARP1 (0.66) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL9887621 | 0.85 | PARP1 (0.71) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL18874527 | 0.84 | PARP1 (0.71) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL9887628 | 0.83 | PARP1 (0.77) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL24625002 | 0.82 | PARP1 (0.69) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL29923429 | 0.82 | PARP1 (0.69) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL29923028 | 0.82 | PARP1 (0.69) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL22656867 | 0.82 | PARP1 (0.75) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL29535734 | 0.82 | PARP1 (0.75) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL29722673 | 0.82 | PARP1 (0.77) | PARP1PARP2TNKSADORA1CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10653805-B2 | Compositions and methods for in vivo imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190201562-A1 | Compositions And Methods For In Vivo Imaging | THE GENERAL HOSPITAL CORPORATION | 2019-07-04 | — | — | US | disclosed |
| US-20180015186-A1 | Compositions And Methods For In Vivo Imaging | THE GENERAL HOSPITAL CORPORATION | 2018-01-18 | — | — | US | disclosed |
| US-9649394-B2 | Compositions and methods for in vivo imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2017-05-16 | — | — | US | disclosed |
| WO-2012074840-A2 | COMPOSITIONS AND METHODS FOR IN VIVO IMAGING | THE GENERAL HOSPITAL CORPORATION (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015186-A1 | Compositions And Methods For In Vivo Imaging | PARP1, PARP11, PARP2 | PARP1 1/4885PARP2 3/4885TNKS 23/4885 |
| US-10653805-B2 | Compositions and methods for in vivo imaging | PARP1, PARP11, PARP2 | PARP1 1/4885PARP2 3/4885TNKS 23/4885 |
| US-20190201562-A1 | Compositions And Methods For In Vivo Imaging | PARP1, PARP11, PARP2 | PARP1 1/4885PARP2 3/4885TNKS 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.