⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15831101 | 0.72 | — | — | |
| SCHEMBL15352250 | 0.72 | — | — | |
| SCHEMBL14463594 | 0.72 | — | — | |
| SCHEMBL19193486 | 0.72 | — | — | |
| SCHEMBL1996162 | 0.65 | — | — | |
| SCHEMBL538510 | 0.61 | — | — | |
| SCHEMBL30711540 | 0.55 | — | — | |
| SCHEMBL8654228 | 0.55 | — | — | |
| Potassium SCHEMBL9146370 | 0.55 | — | — | |
| SCHEMBL7801084 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| US-20230330652-A1 | Machine Learning and Statistical Analysis for Catalyst Structure Prediction and Design | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2023-10-19 | — | — | US | disclosed |
| US-20230255965-A1 | TRPV4 INHIBITOR AS A THERAPEUTIC AGENT FOR OCULAR DISEASES | RAQUALIA PHARMA INC. (JP) | 2023-08-17 | — | — | US | disclosed |
| EP-4183415-A1 | TRPV4 INHIBITOR AS THERAPEUTIC DRUG FOR EYE DISEASE | RaQualia Pharma Inc. (JP) | 2023-05-24 | — | — | EP | disclosed |
| CN-115776890-A | TRPV4 inhibitors as therapeutic agents for eye diseases | 拉夸里亚创药株式会社 | 2023-03-10 | — | — | CN | disclosed |
| EP-4142874-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RaQualia Pharma Inc. (JP) | 2023-03-08 | — | — | EP | disclosed |
| CN-115427409-A | Pyrimidin-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2022-12-02 | — | — | CN | disclosed |
| WO-2021221169-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2021-11-04 | — | — | WO | disclosed |
| EP-3020715-B1 | TETRAZOLINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2021-06-16 | — | — | EP | disclosed |
| EP-2841429-B1 | TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES | SUMITOMO CHEMICAL CO (JP) | 2020-10-21 | — | — | EP | disclosed |
| EP-2841429-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES | Sumitomo Chemical Company Limited (JP) | 2015-03-04 | — | — | EP | disclosed |
| US-20150051171-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-02-19 | — | — | US | disclosed |
| US-20150031733-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-01-29 | — | — | US | disclosed |
| WO-2013162072-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-10-31 | — | — | WO | disclosed |
| WO-2013162077-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-10-31 | — | — | WO | disclosed |
| US-20130131401-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-23 | — | — | US | disclosed |
| US-8378122-B2 | Process for the preparation of chymase modulators | JANSSEN PHARMACEUTICA NV. (BE) | 2013-02-19 | — | — | US | disclosed |
| CN-102869667-A | Tricyclic pyridine derivatives, medicaments containing these compounds, their use and processes for their preparation | BOEHRINGER INGELHEIM INT | 2013-01-09 | — | — | CN | disclosed |
| US-20120309986-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | ANZALONE LUIGI (US) | 2012-12-06 | — | — | US | disclosed |
| US-20120142928-A1 | PROCESS FOR THE PREPARATION OF CATHEPSIN S INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-06-07 | — | — | US | disclosed |