Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626224 | 0.89 | JAK2 (0.42) | GSK3BMAPK14ACVRL1GSK3A | |
| SCHEMBL627636 | 0.86 | ABL1 (0.47) | ABL1 | |
| SCHEMBL9108071 | 0.85 | MAPK14 (0.46) | GSK3BMAPK14GSK3A | |
| SCHEMBL9104647 | 0.85 | CDC7 (0.42) | GSK3BMAPK14GSK3A | |
| SCHEMBL9110056 | 0.85 | MAPK14 (0.41) | GSK3BMAPK14GSK3A | |
| SCHEMBL9104044 | 0.85 | MEN1 (0.40) | GSK3BMAPK14GSK3A | |
| SCHEMBL9105551 | 0.83 | MAPK14 (0.41) | GSK3BMAPK14GSK3A | |
| SCHEMBL9109816 | 0.83 | MAPK8 (0.48) | GSK3BMAPK14GSK3A | |
| SCHEMBL9108971 | 0.83 | GSK3B (0.36) | GSK3BMAPK14GSK3A | |
| SCHEMBL10182180 | 0.83 | GSK3B (0.50) | GSK3BMAPK14ABL1ACVRL1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859768-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, PIK3C2B, PIK3R1 | GSK3B 734/4885MAPK14 1532/4885ABL1 652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.