Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9104044 | 0.91 | MEN1 (0.40) | MEN1KMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL626224 | 0.81 | JAK2 (0.42) | MEN1KMT2AKDM4ESMN1; SMN2USP2 | |
| SCHEMBL9104647 | 0.80 | CDC7 (0.42) | HPGDALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL16167583 | 0.80 | TP53 (0.41) | MEN1KMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL9110056 | 0.79 | MAPK14 (0.41) | KDM4ESMN1; SMN2GSK3BMAPK14NPC1 | |
| SCHEMBL9108071 | 0.78 | MAPK14 (0.46) | MEN1KMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL9109816 | 0.78 | MAPK8 (0.48) | ALDH1A1KDM4ESMN1; SMN2GSK3BMAPK14 | |
| SCHEMBL9105551 | 0.76 | MAPK14 (0.41) | MEN1KMT2AGSK3BMAPK14RAB9A | |
| SCHEMBL9108971 | 0.76 | GSK3B (0.36) | KDM4ESMN1; SMN2GSK3BMAPK14NPC1 | |
| SCHEMBL9106751 | 0.75 | GSK3B (0.37) | KDM4ESMN1; SMN2GSK3BMAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, PIK3C2B, PIK3R1 | MEN1 3292/4885KMT2A 2944/4885HPGD 3886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.