Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989296 | 0.86 | MAPK14 (0.52) | MAPK14CYP3A4CSNK1DCSNK1E | |
| SCHEMBL989245 | 0.85 | MAPK14 (0.47) | MAPK14CYP3A4 | |
| SCHEMBL3997659 | 0.80 | MAPK14 (0.48) | MAPK14CYP3A4 | |
| SCHEMBL990149 | 0.77 | MAPK14 (0.64) | MAPK14CYP3A4 | |
| SCHEMBL3990897 | 0.73 | MAPK14 (0.45) | MAPK14 | |
| SCHEMBL989405 | 0.72 | MAPK14 (0.53) | MAPK14CYP3A4CSNK1DCSNK1E | |
| SCHEMBL989210 | 0.70 | MAPK14 (0.51) | MAPK14CYP3A4CSNK1DCSNK1E | |
| SCHEMBL27654365 | 0.70 | MAPK14 (0.57) | MAPK14CYP3A4 | |
| SCHEMBL17002171 | 0.69 | MAPK14 (0.83) | MAPK14CYP3A4CSNK1DCSNK1E | |
| SCHEMBL8791747 | 0.69 | MAPK14 (0.71) | MAPK14CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863310-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2011-01-04 | — | — | US | disclosed |
| US-20080227839-A1 | Kinase Inhibitors | ELI LILLY AND COMPANY | 2008-09-18 | — | — | US | disclosed |
| EP-1720862-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005080380-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227839-A1 | Kinase Inhibitors | ABL1, MAP3K20, MAP3K19 | MAPK14 341/4885CYP3A4 3973/4885CSNK1D 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.