Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1438098 | 0.92 | MDM2 (0.62) | MDM2GABRA2GABRB2ALDH1A1GRM5 | |
| SCHEMBL9894477 | 0.89 | MDM2 (0.77) | MDM2GABRA2GABRB2TRPM8ALDH1A1 | |
| SCHEMBL9893818 | 0.89 | MDM2 (0.66) | MDM2GRM5JAK2TGFBR1 | |
| SCHEMBL9893679 | 0.89 | MDM2 (0.79) | MDM2GRM5 | |
| SCHEMBL1437392 | 0.88 | MDM2 (0.68) | MDM2GABRA2GABRB2TRPM8L3MBTL1 | |
| SCHEMBL9893992 | 0.87 | MDM2 (0.62) | MDM2GABRA2GABRB2TRPM8L3MBTL1 | |
| SCHEMBL1437142 | 0.87 | MDM2 (0.68) | MDM2GABRA2GABRB2TRPM8ALDH1A1 | |
| SCHEMBL9893417 | 0.86 | MDM2 (0.44) | MDM2GABRA2GABRB2 | |
| SCHEMBL1437573 | 0.84 | MDM2 (0.41) | MDM2GABRA2GABRB2ALDH1A1KDM4E | |
| SCHEMBL9894464 | 0.83 | MDM2 (0.77) | MDM2GABRA2GABRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | MDM2 2/4885GABRA2 4293/4885GABRB2 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.