Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989355 | 0.86 | PIK3CA (0.56) | PIK3CAPIK3CBPIK3CGPIK3C3MAP3K5 | |
| SCHEMBL1041064 | 0.85 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CGPIK3C3MAP3K5 | |
| SCHEMBL1038152 | 0.78 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CGMAP3K5GABRG2 | |
| SCHEMBL1040000 | 0.73 | PIK3CA (0.55) | PIK3CAPIK3CBPIK3CGPIK3C3PIK3CD | |
| SCHEMBL988715 | 0.72 | PIK3CA (0.54) | PIK3CAPIK3CBPIK3CGPIK3C3MAP3K5 | |
| SCHEMBL13655120 | 0.72 | PIK3CA (0.49) | PIK3CAPIK3CBPIK3CGPIK3C3PIK3CD | |
| SCHEMBL1041185 | 0.72 | PIK3CA (0.63) | PIK3CAPIK3C3PIK3CD | |
| SCHEMBL1078672 | 0.71 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CGPIK3C3PIK3CD | |
| SCHEMBL989959 | 0.71 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CGMAP3K5GABRG2 | |
| SCHEMBL1039578 | 0.71 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGPIK3C3PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |