Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989315 | 0.87 | PIK3CA (0.68) | PIK3CAPIK3CB | |
| SCHEMBL12535826 | 0.77 | PIK3CA (0.77) | PIK3CAPIK3CBTP53MAPT | |
| SCHEMBL989606 | 0.77 | PIK3CA (1.00) | PIK3CAPIK3CB | |
| SCHEMBL988058 | 0.77 | PIK3CA (0.67) | PIK3CAPIK3CBTP53MAPT | |
| SCHEMBL988314 | 0.74 | PIK3CA (0.80) | PIK3CAPIK3CB | |
| SCHEMBL989168 | 0.73 | PIK3CA (0.81) | PIK3CAPIK3CB | |
| SCHEMBL990615 | 0.72 | PIK3CA (0.73) | PIK3CAPIK3CB | |
| SCHEMBL988227 | 0.72 | PIK3CA (0.63) | PIK3CAPIK3CB | |
| SCHEMBL989360 | 0.70 | PIK3CA (0.83) | PIK3CAPIK3CB | |
| SCHEMBL989208 | 0.70 | PIK3CA (0.82) | PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |